Repair Your Cardiovascular System Improvements demonstrated within 2 hours*

 Adenosine Triphosphate deficiency

ATP (adenosine triphosphate) can be used to increase the blood flow without increasing blood pressure. In an experiment, 11 healthy males were given 1 gram of ATP each. Two hours after administration blood flow was demonstrated to increase up to 58% in arteries.

ATP facilitates greater oxygen intake to the brain and vital organs which promotes accelerated healing at the cellular level.

Adenosine triphosphate (ATP) is a biological substance that stores the energy that the body needs for a wide variety of metabolic functions. In fact all the physiological mechanisms that need energy get it from ATP or one of its derivatives stored in cells. The breakdown of ATP releases energy which is then used as fuel for all our bodily functions. ATP is needed for the heart to beat, it is needed for muscular effort, in fact everything we do requires ATP as energy.

The body cannot function without ATP. That is why ATP is known as the “energy currency”.  Each cell in your body must be supplied with energy continuously if it is to function correctly. Therefore when the cells in the body do not make ATP, because of low oxygen levels, the cells act anaerobically and lactate is produced.

Lactate Can Create Muscular Pain

Muscle fiber degeneration and regeneration, inflammation in intramuscular connective tissue, and hypoxia (low oxygen to the cell) occur with sustained muscular action. Severe muscle pain develops in this low oxygen environment. A combination of muscle tension and muscle hypoxia is the likely cause the chronic heart disease muscle pain syndrome, called angina.

Ischaemic or ischemic heart disease (IHD), or myocardial ischaemia, is a disease characterized by reduced blood supply to the heart muscle, usually due to coronary artery disease (atherosclerosis of the coronary arteries). Its risk increases with age, smoking, hypercholesterolemia (high cholesterol levels), diabetes, hypertension (high blood pressure) and is more common in men and those who have close relatives with ischaemic heart disease.
Symptoms of stable ischaemic heart disease include angina (characteristic chest pain on exertion) and decreased exercise tolerance. Unstable IHD presents itself as chest pain or other symptoms at rest, or rapidly worsening angina. It is the most common cause of death in most Western countries, and a major cause of hospital admissions. There is limited evidence for benefits of population screening. Prevention, by implementing a healthy diet and supplements to correct diabetes, cholesterol, and high blood pressure is used both to prevent IHD and to decrease the risk of complications.

With ample oxygen, the body is able to produce all the ATP it needs to maintain a healthy existence. However, when oxygen is low, for example during strenuous exercise, Thrombus occurs. The body may not be able to replace ATP fast enough during strenuous exercise. In order to achieve maximum athletic performance, as well as for overall health, it is important to keep ATP at the optimum level. ATP is critical for heart health as well as the health of all the other musculature in the body that allows us to function.

ATP not only keeps your heart beating, it also keeps oxygen circulating around your body which is vital for muscles to operate and for them to recover and develop. If ATP levels continue to be depleted, you may face a deficiency.

Thrombus

Taussig and Nieper, 1979, Kelly, 1996 showed:
Bromelain inhibits thrombus formation; studies have shown that bromelain prevents aggregation of human blood platelets in vivo in vitro e.g., Petri dish and human experiments. Both of the researches also demonstrated that bromelain prevents or minimizes the severity of angina and Transient Ischemic Attacks (TIA), which is a "warning stroke" or "mini-stroke" that produces stroke-like symptoms but no lasting damage. Recognizing and treating TIA's can reduce your risk of a major stroke.

Taussig and Nieper, 1979 and later, Hale et al, 2002, showed that in vitro bromelain treatment of leukocytes (white blood cells), markers studied, induced loss of CD41 and CD42A via enzymatic digestion, and also decreased platelet function, thus inhibiting thrombosis formation.

Oxygen and Nutrients Absorption

Taussig, Nieper and Kelly et. al, suggested that bromelain increases vessels' wall permeability to oxygen and nutrients while at the same time thinning the blood.

Heart Attach or Stroke

(Kelly, 1996).  Heinicke et al. (1972) were the first to report that bromelain prevents abnormal clump together of blood platelets, using fibrinogen in the process. Their study was carried out among human volunteers with a history of heart attach or stroke, some with high fibrinogen values, as well as healthy subjects. Their study found that oral administration of bromelain (160-1000mg per day) decreased aggregation of blood platelets in all the subjects.

Stable Angina

Nieper in (1978), administered 400-1000mg per day of bromelain to 14 patients with stable angina. The study resulted in the disappearance of symptoms in all patients within 4 to 90 days, but reappeared after bromelain administration was discontinued. The ability of bromelain to influence these conditions could be due to its ability to breakdown fibrinous plaques, and to dissolve atherosclerosis plaque.

Nattokinase is an enzyme found in Nattō, a popular Japanese cheese made from fermented soybeans. Nattō is produced by a fermentation process by adding Bacillus Nattō, a beneficial bacterium, to boiled soybeans. The enzyme is then purified and isolated into a powdered form so that it can be used in a capsule or tablet. Unlike aspirin and most other anticoagulant drugs which interfere with fibrin production, Nattokinase acts “directly on the fibrin that binds platelets and red blood cells that form blood clots. Nattokinase has the ability to help your cardiovascular system in three specific ways:

1.Thrombolytic Effect: Nattokinase dissolves existing thrombus (clotting) by dissolving the fibrin that binds platelets together. Nattō acts much like plasmin, the only enzyme produced by the human body that breaks down fibrin. As we age, our plasmin production decreases, making Nattō supplementation the ideal replacement. Nattokinase also enhances the body’s own production of plasmin and other blood clotting agents, including urokinase (endogenous) (Sumi, H. et al. “A novel fibrinolytic enzyme (Nattokinase) in the vegetable cheese Nattō….” Experientia 1987, 43:1110-11).

2. Blood Pressure: Nattokinase has been shown to lower blood pressure levels. People in Japan have been eating Nattō for this purpose for hundreds of years. Studies have shown it lowers blood pressure by inhibiting angiogenesis converting enzyme (ACE). Ace causes blood vessels to narrow and blood pressure to rise. Nattokinase’s ability to inhibit ACE, therefore, has a lowering effect on blood pressure (Maruyama M, Sumi H. Effect of Nattō Diet on Blood Pressure. JTTAS,1995.).

3. Circulation Enhancement: Nattokinase has been shown to aid in blood flow by assisting in the clearing of circulation. It has also been shown to help prevent the hardening and narrowing of arteries (Sumi H. Healthy Microbe "Bacillus Nattō". Japan Bio Science Laboratory Co. Ltd.). As good as all of these benefits sound, obtaining the correct amounts of Nattokinase is essential if you are expecting to get real results. So, in order to make sure we had the right amounts, we went back and reviewed Dr. Sumi’s original research. The research showed that Nattō has an average of 40 fibrinolytic units per gram (fibrinolytic units are a determination of how much fibrin a specific amount of the enzyme breaks up in a test tube). In human clinical trials, dosages of between 50 and 200 grams of Nattō per day were shown to be effective in humans. This would equate to between 2,000 and 8,000 fibrinolytic units (Sumi H. Interview with Doctor of Medicine Hiroyuki Sumi. Japan Bio Science Laboratory Co. Ltd.). Therefore, just 4- 500mg capsules per day equal the amounts used in the studies of 2,000-8,000 fibrinolytic units. If you are dealing with heart disease, 4 capsules per day should be adequate. However, if you are healthy and just looking to maintain your good health, we strongly recommend that you only consume one (1) or two (2) capsules per day.

Lipase Deficiency

Lipase is made in the pancreas, secreted in the duodenum, migrates into the gut, then into the cardiovascular system, where Lipase also functions in the blood to enzymatically act on the triacylglycerides converting it into very low density lipoprotein so that cells can take up the free fatty acids as energy.

For example, pancreatic lipase, which is the key enzyme to break down fats in the human digestive system, converts triglyceride substrates found in ingested oils to monoglycerides and free fatty acids. Regarding the amount and nature of lipids, diets rich in polyunsaturated fatty acid, mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to reduce the risk of coronary heart disease. These substances can be made using lipase inside the human body

What Is Cholesterol? What Are Triglycerides?

Cholesterol and triglycerides are two forms of lipids, or fats. Both cholesterol and triglycerides are necessary for life itself. Cholesterol is necessary, among other things, for building cell membranes and for making several essential hormones. Triglycerides, which are chains of high-energy fatty acids, provide much of the energy needed for cells to function. But when one is deficient in lipase the body cannot use the cholesterol lipids, that is to say, the fat.  

Lipase deficiency increases plasma triglycerides and reduces HDL levels and may thereby predispose carriers to ischemic heart disease. These findings were published in American Heart Association, Inc. Børge G. Nordestgaard, et al., Circulation. 2000;101:2393-2397. Nine thousand, two hundred, fifty-nine (9,259) individuals were studied for lipase deficiency. When lipase was corrected in serum,  heart disease decreased. The lipoprotein lipase was found to degrade the triglycerides contained in chylomicrons (chylomicrons are large lipoprotein particles that consist of triglycerides (85-92%), phospholipids (6-12%), cholesterol (1-3%) and proteins (1-2%) , and very-low-density lipoproteins).

Pancreatic Protease

A.H. Elliot et al., published his finding in 1931; he demonstrated that taking pancreatic enzymes treated the cause of Angina, which is a disease of the cardiovascular system. He described the increase in the coronary flow as allowing adequate oxygen and essential nutrients through, thus feeding the heart. The body's antagonisms to the hypertension is created by a restricted cardiovascular system, caused by low blood oxygen levels, creating anaerobic cell respiration, creating lactate in the heart muscle, and leading to adrenalin production: "the fight or flight hormone".  The action above describes the beneficial usage of  Trypsin, Chymotrypsin, Elastase, Carboxypeptidase A1, A2, and Carboypeptidase B, also known as pancreatic protease. The actions explained by Dr. Elliot explained the beneficial influence of pancreatic enzymes in cleaning the debris and fibrin from the cardiovascular system, (fibrin is made from fibrinogen, a soluble plasma glycoprotein that is synthesized by the liver.). As we age, fibrin accumulates in the cardiovascular system . By cleaning the blood of fibrin, blood flow and oxygen is increased.

What are the Symptoms of Angina?

Chest pain or discomfort that typically occurs with activity or stress when more oxygen is required is a symptom of angina. The pain usually begins slowly and gets worse over the next few minutes before going away.

• A feeling of indigestion or heartburn
• Dizziness or light-headedness
• Nausea, vomiting, and cold sweats
• Palpitations
• Shortness of breath
• Unexplained tiredness after activity (more common in women)

Causes

Your heart muscle is working all the time, so it needs a continuous supply of oxygen. This oxygen is provided by the coronary arteries, which carry blood. When the heart muscle has to work harder, it needs more oxygen. Symptoms of angina occur when the coronary arteries are narrowed or blocked by hardening of the arteries (atherosclerosis), or by a blood clot. The most common cause of angina is coronary heart disease (CHD). Angina pectoris is the medical term for this type of chest pain. Stable angina is predictable chest pain. Although less serious than unstable angina, it can be very painful or uncomfortable. Anything that requires the heart muscle to need more oxygen can cause an angina attack, including:

• Cold weather
• Exercise
• Emotional tension
• Large meals

Other causes of angina include:

• Abnormal heart rhythms
• Anemia
• Coronary artery spasm (also called Prinzmetal's angina)
• Heart failure
• Heart valve disease
• Hyperthyroidism

Q10

This unique vitamin-like substance is present in every cell of the body, especially the heart. Q10 levels are reported to decrease with age and to be low in patients with cardiovascular disease. Q10 decreases the proliferation of free radicals, supporting a healthy immune system. Q10 also stimulates the metabolism to aid your body in the conversion of food to energy and aids in the reductions of cellular oxidation.
An excerpt from an article of the National Academy of Science states, “Therapy with CoQ10 can result in increasing and even normalizing the myocardial levels of CoQ10. Therapy with CoQ10 can result in a…profound increase both in cardiac function and in the quality of life of a failing cardiac patient. Cardiomyopathy (any disease that affects the structure and function of the heart) can be substantially, but not solely, a consequence of a deficiency of CoQ10.”

In a 90-day study, 2500 patients with congestive heart failure were given CoQ10. The percentages of patients with symptomatic improvement were as follows: sweating 82.4%, jugular reflux 81.5%, bluish skin discoloration 81%, lung noise 78.4%, fluid retention in organs 76.9%, awareness of heartbeat 75.7%, vertigo 73%, irregular heart beats 62%, insomnia 60.2%, shortness of breath 54.2%, night time urination 50.7%, enlargement of the liver area 49.3%.

Q10 Precursor to ATP

Q10 is essential for electron transport within the mitochondria and hence for ATP generation and cellular energy production.

Clinical Aspects of CoQ10 Primary CoQ10 Deficiency

Ogashara, et al, described the first patients (two sisters) with primary CoQ10 deficiency in 1989.  The patients, aged 12 and 14, had progressive muscle weakness, abnormal fatigue, and central nervous system dysfunction from early childhood. The CoQ10 concentration in their muscles was markedly decreased, being about 5% of normal, but was normal in serum and cultured fibroblasts. It was concluded that the primary defect in these sisters probably involved a tissue-specific isozyme in the CoQ10 synthetic pathway of muscle and brain, and both patients improved remarkably with oral CoQ10

CoQ10 and Statin Myopathy

De Pinieux G, et al, Lipid-lowering drugs and mitochondrial function: Br J Clin Pharmacol 1996;42:333-7.
Studies have indicated up to 13.6% of statin treated patients experience some degree of  myopathy (muscle weakness), and as targets for cholesterol reduction become progressively lower, necessitating higher statin doses. The risk of side effects, particularly myopathies, has increased. A number of studies have provided evidence of impaired mitochondrial function in statin-induced myopathy. Also observed was significant elevations in the lactate to pyruvate ratio, an indirect marker of mitochondrial dysfunction. Abnormalities resolved following discontinuation of statin therapy was confirmed in the patients who had repeat biopsies.

CoQ10 and Hypertension

A recent meta-analysis of Q10 in the treatment of hypertension (12 clinical trials, 362 patients) concluded that, in hypertensive patients, CoQ10 has the potential to lower systolic and diastolic blood pressure, without significant side effects. A blood pressure lowering effect of CoQ10 was found across three types of studies including randomised controlled, crossover, and open label. Decreases in systolic blood pressure ranged from 11 to 17 mmHg and in diastolic blood pressure from 8 to 10 mmHg. Rosenfeldt FL, et al. Coenzyme Q10 in the treatment of hypertension: meta-analysis of the clinical trials. J Hum Hypertens 2007;21:297-306.

The antihypertensive effect of CoQ10 occurs gradually over several months, and the CoQ10 dose required for effectiveness varies between patients. Mol Aspects Med 1994;15 (Suppl):S265-72.  Langsjoen P, et al

Sarrapeptase

The Miracle Silk Worm Enzyme!

Serrapeptase digests non-living tissue, blood clots, cysts, and arterial plaque and helps to lower inflammation in all forms including C-Reactive Proteins. In fact, the late German physician, Dr. Hans Nieper, used Serrapeptase successfully to treat arterial blockage in his coronary patients. Serrapeptase protects against stroke and is reportedly more effective and quicker than EDTA Chelation treatments in removing arterial plaque. Dr. Nieper also reported that Serrapeptase dissolves blood clots and causes varicose veins to shrink or diminish. Dr. Nieper told of a woman scheduled for hand amputation and a man scheduled for bypass surgery who both recovered quickly without surgery after treatment with Serrapeptase.

Serrapeptase may well offer additional cardiovascular benefits not considered by Nieper. In particular, researchers have recently proposed that inflammation contributes to the development of arterial blockage. In one study, subjects with higher levels of CRP (C-Reactive Protein*, a marker for systemic inflammation) were found to have a greater risk of future heart attack and stroke, independently of other risk factors such as smoking, high blood pressure, or cholesterol levels.  

Subjects with the highest levels of CRP who also used aspirin, however, showed dramatic decreases in their risk of heart attack, leading the researchers to speculate that the effectiveness of aspirin in preventing heart attack is due as much to its anti-inflammatory activity as to its anticlotting effects.

Serrapeptase, like aspirin, has both anti-inflammatory and anticlotting properties. In contrast to aspirin, however, serrapeptase can melt through existing fibrous deposits. Serrapeptase also lacks the serious gastrointestinal side effects associated with chronic use of NSAID's such as aspirin.

This combination of properties makes serrapeptase just about the perfect remedy for warding off cardiovascular disease, better even than the proverbial aspirin a day. It’s beginning to look more and more as though Dr. Nieper was right—serrapeptase is indeed a “miracle” enzyme.

Because serrapeptase is a blood-thinning agent, it’s wise to consult your physician if you’re already taking any form of anticoagulant therapy such as Warfarin. Despite these cautions, however, serrapeptase has an excellent tolerability profile in general.

*The C-reactive protein (CRP) test is a blood test that measures the level an inflammatory marker – a substance that the body releases in response to inflammation. High levels of CRP in the blood means there is inflammation somewhere in the body.  

**Warfarin is prescribed to people with an increased tendency for thrombosis or as secondary prophylaxis (prevention of further episodes) in those individuals that have already formed a blood clot (thrombus). Warfarin treatment can help prevent formation of future blood clots and help reduce the risk of embolism (migration of a thrombus to a spot where it blocks blood supply to a vital organ). Common clinical indications for warfarin use are artial fibrillation, the presence of artificial heart valves, deep venous thrombosis, pulmonary embolism, antiphospholipid syndrome and, occasionally, after heart attacks (myocardial infarction).

The most common symptom of coronary artery disease is angina, or chest pain. Angina can be described as a discomfort, heaviness, pressure, aching, burning, fullness, squeezing, or painful feeling in your chest. It can be mistaken for indigestion or heartburn.

Angina is usually felt in the chest, but may also be felt in the shoulders, arms, neck, throat, jaw, or back.
Other symptoms of coronary artery disease include:

• Shortness of breath
• Palpitations (irregular heart beats, skipped beats, or a "flip-flop" feeling in your chest)
• A faster heartbeat
• Weakness or dizziness
• Nausea
• Sweating

Symptoms of Arrhythmias

When symptoms of arrhythmias, or an abnormal heart rhythm, are present, they may include:

• Palpitations (a feeling of skipped heart beats, fluttering or "flip-flops," or feeling that your heart is "running away").
• Pounding in your chest.
• Dizziness or feeling light-headed.
• Fainting.
• Shortness of breath.
• Chest discomfort.
• Weakness or fatigue (feeling very tired)

Symptoms of Atrial Fibrillation

Atrial fibrillation (AF) is a type of arrhythmia. Most people with AF experience one or more of the following symptoms:

• Heart palpitations (a sudden pounding, fluttering, or racing feeling in the heart).
• Lack of energy; tired.
• Dizziness (feeling faint or light-headed).
• Chest discomfort (pain, pressure, or discomfort in the chest).
• Shortness of breath (difficulty breathing during activities of daily living).

Some patients with artial fibrillation have no symptoms. Sometimes these episodes are briefer.
Allopathic doctors prescribe numerous drugs to mask CVD, this only make the problem worst over time.

An important thing to understand when wanting to correct your health, is that masking the problem to improve the numbers is not healthy and causes more harm to your health in the long term.

Symptoms of a heart attack can include:

• Discomfort, pressure, heaviness, or pain in the chest, arm, or below the breastbone
• Discomfort radiating to the back, jaw, throat, or arm
• Fullness, indigestion, or choking feeling (may feel like heartburn)
• Sweating, nausea, vomiting, or dizziness
• Extreme weakness, anxiety, or shortness of breath
• Rapid or irregular heartbeats

During a heart attack, symptoms typically last 30 minutes or longer and are not relieved by rest or oral medications (medications taken by mouth). Initial symptoms can start as a mild discomfort that progresses to significant pain.
Some people have a heart attack without having any symptoms (a "silent" MI). A silent MI can occur among all people, though it occurs more often among diabetics.
If you think you are having a heart attack, DO NOT DELAY. Call for emergency help (dial 911 in most areas). Immediate treatment of a heart attack is very important to lessen the amount of damage to your heart.